ARHGAP35

Name

Rho GTPase activating protein 35

Type

protein-coding

Position

46,860,997–47,005,077 (+)

Aliases

GRF-1, GRLF1, P190-A, P190A, p190ARhoGAP, p190RhoGAP

Ensembl

ENSG00000160007

RefSeq RNA

NM_004491.5, NM_024342.1, XM_024451473.2, XM_054320752.1, XR_002958305.2

RefSeq protein

NP_004482.4, XP_024307241.1, XP_054176727.1

The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008].

via MyGene.info

Wikidata facts

Image

Protein ARHGAP35 PDB 2K85.png

via Wikidata · CC0