CD72 molecule
Sign in to saveAlso known as CD72 antigen, lyb-2, B-cell differentiation antigen CD72, CD72
CD72 (Cluster of Differentiation 72), also known in murine biology as Lyb-2, is a protein active in the immune system of animals. It consists of two identical halves, each of about 39-43 kD, and is a C-type lectin. Its primarily locus of expression is B-cells (from the pro-B through the mature B-cell stage), where it appears to mediate aspects of B-cell - T-cell interaction. It is a ligand for CD5.
In the Vinony graph
Within Vinony's link graph, CD72 molecule is referenced by 361 other articles, and connects out to human chromosome 9, CD1 and protein.
Vinony files it under Clusters of differentiation, Genes on human chromosome 9 and Protein pages needing a picture.
Its subject is documented across 8 Wikipedia language editions.
Protein · UniProt
B-cell differentiation antigen CD72
- Gene
- CD72
- Organism
- Homo sapiens (Human)
- Length
- 359 aa
- Molecular mass
- 40,220 Da
- Evidence
- 1: Evidence at protein level
Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Also acts as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis
Swiss-Prot (reviewed) · via UniProt
Wikidata facts
- Instance of
- protein
Show 2 more facts
- biological process
- signal transduction
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0
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Encyclopedic overview
3 sectionsContents
- See also
- References
- External links
CD72 (Cluster of Differentiation 72), also known in murine biology as Lyb-2, is a protein active in the immune system of animals. It consists of two identical halves, each of about 39-43 kD, and is a C-type lectin. Its primarily locus of expression is B-cells (from the pro-B through the mature B-cell stage), where it appears to mediate aspects of B-cell - T-cell interaction. It is a ligand for CD5.
CD72 is a regulatory protein on B lymphocytes. The cytoplasmic tail of CD72 contains two potential immunoreceptor tyrosine-based inhibitory motifs, one of which has been shown to recruit the tyrosine phosphatase SHP- 1. These features suggest a negative regulatory role for CD72. CD72 is a nonredundant regulator of B-cell development and a negative regulator of B-cell responsiveness.
Excerpted from Wikipedia’s “CD72 molecule” article, available under the CC BY-SA 4.0 licence.