Structure via PubChem · Public domain (PubChem)
droxicam
Sign in to saveDroxicam is a non-steroidal anti-inflammatory drug of the oxicam class. A prodrug of piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis. ==Synthesis== class=skin-invert-image|500px When heated, phenyl pyridin-2-ylcarbamate (1) decomposes to 2-isocyanatopyridine (2) which reacts with the heterocyclic compound (3) to give droxicam.
In the Vinony graph
Vinony's link graph records 279 inbound references to droxicam, and connects out to salicylic acid, non-steroidal anti-inflammatory drug and metamizole sodium.
It is catalogued under topics including 2-Pyridyl compounds, Carbamates and Chemical pages without DrugBank identifier.
Vinony links it to 9 Wikipedia language editions.
Chemical data
- Formula
- C16H11N3O5S
- Molecular weight
- 357.3 g/mol
- IUPAC name
- 5-methyl-6,6-dioxo-3-pyridin-2-yl-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4-dione
- SMILES
- CN1C2=C(C3=CC=CC=C3S1(=O)=O)OC(=O)N(C2=O)C4=CC=CC=N4
- InChIKey
- OEHFRZLKGRKFAS-UHFFFAOYSA-N
- XLogP
- 1.2
- Polar surface area
- 105 Ų
- H-bond donors
- 0
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- rheumatic disease
via ChEMBL · EBI
Research
52 papers- Pharmacological profile of droxicam.General pharmacology · 1988
- Pharmacokinetic profile of droxicam.European journal of rheumatology and inflammation · 1991
- Droxicam: a pharmacological and clinical review of a new NSAID.European journal of rheumatology and inflammation · 1991
- [Droxicam-induced hepatitis. Description of 3 new cases and review of the literature].Revista clinica espanola · 1994
- Pharmacological properties of droxicam, a new non-steroidal anti-inflammatory agent.Methods and findings in experimental and clinical pharmacology · 1986
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 357.041941
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₆H₁₁N₃O₅S
- canonical SMILES
- CN1C2=C(C3=CC=CC=C3S1(=O)=O)OC(=O)N(C2=O)C4=CC=CC=N4
- World Health Organisation international non-proprietary name
- droxicam
- subject has role
- non-steroidal anti-inflammatory drug
- Commons category
- Droxicam
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Droxicam is a non-steroidal anti-inflammatory drug of the oxicam class. A prodrug of piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis. ==Synthesis== class=skin-invert-image|500px When heated, phenyl pyridin-2-ylcarbamate (1) decomposes to 2-isocyanatopyridine (2) which reacts with the heterocyclic compound (3) to give droxicam.
== References ==
Excerpted from Wikipedia’s “droxicam” article, available under the CC BY-SA 4.0 licence.
Gallery (2)
Available in 9 languages
via Wikidata sitelinks · CC0