EDNRB
Sign in to saveAlso known as ABCDS, ET-B, ET-BR, ETB, ETBR, ETRB, HSCR, HSCR2
protein-coding gene in the species Homo sapiens
In the Vinony graph
Vinony's link graph records 556 inbound references to EDNRB, and connects out to PubMed, Ensembl genome database project and zygosity.
It sits within the topics Genes on human chromosome 13 and G protein-coupled receptors.
Vinony links it to 7 Wikipedia language editions.
Gene data
EDNRB- Name
- endothelin receptor type B
- Type
- protein-coding
- Position
- 77,895,481–77,975,529 (−)
- Aliases
- ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A
- Ensembl
- ENSG00000136160
- RefSeq RNA
- NM_000115.5, NM_001122659.3, NM_001201397.2, NM_003991.4, NR_047024.1
- RefSeq protein
- NP_000106.1, NP_001116131.1, NP_001188326.1, NP_003982.1
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
endothelin receptor type B
- Symbol
- EDNRB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 13:77,895,481-77,975,529
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 89
- exact match
- identifiers.org/ncbigene/1910
- found in taxon
- Homo sapiens
- genomic end
- 77975529
- genomic start
- 78469616
- chromosome
- human chromosome 13
- cytogenetic location
- 13q22.3
via Wikidata · CC0