Early growth response protein 2 (EGR2), also known as Krox20, is a transcription factor encoded by the EGR2 gene in humans. It is highly expressed in migrating neural crest cells and later in neural crest-derived cells of the cranial ganglia. Expression of EGR2 is restricted to early hindbrain development, and the gene is evolutionarily conserved among vertebrates, including humans, mice, chicks, and zebrafish. The conservation of its amino acid sequence and embryonic expression pattern underscores its essential role in hindbrain segmentation and neural differentiation.
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
via MyGene.info
Early growth response protein 2 (EGR2), also known as Krox20, is a transcription factor encoded by the EGR2 gene in humans. It is highly expressed in migrating neural crest cells and later in neural crest-derived cells of the cranial ganglia. Expression of EGR2 is restricted to early hindbrain development, and the gene is evolutionarily conserved among vertebrates, including humans, mice, chicks, and zebrafish. The conservation of its amino acid sequence and embryonic expression pattern underscores its essential role in hindbrain segmentation and neural differentiation.
== Structure == The EGR2 protein contains three tandem C2H2-type zinc finger domains that mediate specific DNA binding. These zinc fingers enable EGR2 to function as a transcriptional regulator of genes involved in neural development and myelination.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).