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GeneQ17916634· pop 7· linked from 814 articles

ELK4

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Also known as SAP1, ELK4, ETS transcription factor, ETS transcription factor ELK4

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.

Gene data

ELK4

Name: ETS transcription factor ELK4
Type: protein-coding
Position: 205,597,556–205,634,520 (−)
Aliases: SAP1
Ensembl: ENSG00000158711
RefSeq RNA: NM_001973.4, NM_021795.3
RefSeq protein: NP_001964.2, NP_068567.1

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II cell differentiation negative regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding chromatin binding DNA-binding transcription factor activity DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleoplasm

Pathways

MAPK signaling pathway - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Transcriptional misregulation in cancer - Homo sapiens (human)Mesodermal commitment pathway MAPK Signaling Pathway EGF-EGFR signaling pathway ID signaling pathway Serotonin Receptor 2 and ELK-SRF-GATA4 signaling Serotonin Receptor 4-6-7 and NR3C Signaling

via MyGene.info

Wikidata facts

Image: Protein ELK4 PDB 1bc7.png

Show 5 more facts

HomoloGene ID: 1492
exact match: identifiers.org/ncbigene/2005
genomic end: 205632011
genomic start: 205577071
cytogenetic location: 1q32.1

Sources (3)

via Wikidata · CC0

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Article

5 sections

Contents

Function
Interactions
References
Further reading
External links

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.

== Function ==

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Categories

Genes on human chromosome 1 Transcription factors