ethoxzolamide

Also known as ethoxazolamide, ethoxyzolamide, 6-ethoxybenzothiazole-2-sulfonamide, 6-ethoxy-2-benzothiazolesulfonamide, 6-ethoxy-1,3-benzothiazole-2-sulfonamide

Ethoxzolamide (alternatively known as ethoxyzolamide) is a sulfonamide medication that functions as a carbonic anhydrase inhibitor. It is used in the treatment of glaucoma and duodenal ulcers, and as a diuretic. It may also be used in the treatment of some forms of epilepsy.

Chemical data

Formula: C9H10N2O3S2
Molecular weight: 258.3 g/mol
IUPAC name: 6-ethoxy-1,3-benzothiazole-2-sulfonamide
SMILES: CCOC1=CC2=C(C=C1)N=C(S2)S(=O)(=O)N
InChIKey: OUZWUKMCLIBBOG-UHFFFAOYSA-N
XLogP: 2
Polar surface area: 119 Å²
H-bond donors: 1
H-bond acceptors: 6
Formal charge: 0

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Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1982
Admin. routes: oral

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Wikidata facts

Subclass of: chemical compound
Mass: 258.013
Has use: medication

Show 4 more facts

chemical formula: C₉H₁₀N₂O₃S₂
canonical SMILES: CCOC1=CC2=C(C=C1)N=C(S2)S(=O)(=O)N
subject has role: carbonic anhydrase inhibitor
Commons category: Ethoxzolamide

Sources (3)

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Encyclopedic overview

5 sections

Contents

Pharmacology
Mechanism of action
Synthesis
See also
References

==Pharmacology== Ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold. This reduction in carbonic anhydrase also reduces the intraocular pressure in the eye by decreasing aqueous humor.

Excerpted from Wikipedia’s “ethoxzolamide” article, available under the CC BY-SA 4.0 licence.

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