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fluproquazone
Sign in to saveFluproquazone (trade name Tormosyl, RF 46-790 ) was a quinazolinone derivative with potent analgesic, antipyretic, and anti-inflammatory effects discovered by Sandoz. It was withdrawn during development due to liver toxicity.
In the Vinony graph
Vinony's link graph records 278 inbound references to fluproquazone, and connects out to salicylic acid, metamizole sodium and clonixin.
Vinony files it under 4-Fluorophenyl compounds, Abandoned drugs and Chemical pages without DrugBank identifier.
Vinony links it to 6 Wikipedia language editions.
Chemical data
- Formula
- C18H17FN2O
- Molecular weight
- 296.3 g/mol
- IUPAC name
- 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one
- SMILES
- CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=C(C=C3)F
- InChIKey
- ZWOUXWWGKJBAHQ-UHFFFAOYSA-N
- XLogP
- 4.1
- Polar surface area
- 32.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
28 papers- Fluproquazone (Tormosyl).Arzneimittel-Forschung · 1981
- Fluproquazone for osteoarthritis.Rheumatology and rehabilitation · 1981
- Toxicological evaluation of fluproquazone.Arzneimittel-Forschung · 1981
- Analgesic effect of fluproquazone in postoperative patients.Clinical pharmacology and therapeutics · 1980
- Antipyretic activity of fluproquazone in man.Arzneimittel-Forschung · 1981
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 296.132
Show 3 more facts
- chemical formula
- C₁₈H₁₇FN₂O
- canonical SMILES
- CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=C(C=C3)F
- subject has role
- non-steroidal anti-inflammatory drug
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Fluproquazone (trade name Tormosyl, RF 46-790 ) was a quinazolinone derivative with potent analgesic, antipyretic, and anti-inflammatory effects discovered by Sandoz. It was withdrawn during development due to liver toxicity.
== References ==
Excerpted from Wikipedia’s “fluproquazone” article, available under the CC BY-SA 4.0 licence.