FOXN1

Name

forkhead box N1

Type

protein-coding

Position

28,506,243–28,538,900 (+)

Aliases

FKHL20, RONU, TIDAND, TIDTA, TLIND, WHN

Ensembl

ENSG00000109101

RefSeq RNA

NM_001369369.1, NM_003593.3, XM_011525358.2, XM_011525359.2, XM_011525362.2

RefSeq protein

NP_001356298.1, NP_003584.2, XP_011523660.1, XP_011523661.1, XP_011523664.1

Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008].

via MyGene.info

Wikidata facts

via Wikidata · CC0