HES5

Also known as bHLHb38, hes family bHLH transcription factor 5

Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.

In the Vinony graph

Vinony's link graph records 813 inbound references to HES5, and connects out to epithelium, PubMed and human chromosome 1.

It sits within the topics Genes on human chromosome 1 and Transcription factors.

Vinony links it to 5 Wikipedia language editions.

Gene data

HES5

Name: hes family bHLH transcription factor 5
Type: protein-coding
Position: 2,528,745–2,530,271 (−)
Aliases: bHLHb38
Ensembl: ENSG00000273529
RefSeq RNA: NM_001010926.4, XM_005244751.5, XM_054328605.1, XM_054336501.1
RefSeq protein: NP_001010926.1, XP_005244808.1, XP_054184580.1, XP_054192476.1

This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II chondrocyte differentiation regulation of DNA-templated transcription cell adhesion Notch signaling pathway Notch signaling pathway smoothened signaling pathway

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA binding protein dimerization activity sequence-specific double-stranded DNA binding

Cellular component

chromatin nucleus nucleus nucleoplasm

Pathways

Notch signaling pathway - Homo sapiens (human)Human papillomavirus infection - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Breast cancer - Homo sapiens (human)Signaling by NOTCH Signaling by NOTCH Signal Transduction Signal Transduction Disease Signaling by NOTCH1

via MyGene.info

Gene · Ensembl

hes family bHLH transcription factor 5

Symbol: HES5
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:2,528,745-2,530,271
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

exact match: identifiers.org/ncbigene/388585
HomoloGene ID: 7755
cytogenetic location: 1p36.32
found in taxon: Homo sapiens
chromosome: human chromosome 1
genomic start: 2460184
genomic end: 2530263
expressed in: putamen

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

3 sections

Contents

References
Further reading
External links

Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.

HES5 regulates the development of the early brain by maintaining stem cell neural progenitors in the ventricular zone. HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia. Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.

Excerpted from Wikipedia’s “HES5” article, available under the CC BY-SA 4.0 licence.