HES5

Also known as bHLHb38, hes family bHLH transcription factor 5

Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.

Gene data

HES5

Name: hes family bHLH transcription factor 5
Type: protein-coding
Aliases: bHLHb38

This gene encodes a member of a family of basic helix-loop-helix transcriptional repressors. The protein product of this gene, which is activated downstream of the Notch pathway, regulates cell differentiation in multiple tissues. Disruptions in the normal expression of this gene have been associated with developmental diseases and cancer. [provided by RefSeq, Dec 2008].

via MyGene.info

Gene · Ensembl

hes family bHLH transcription factor 5

Symbol: HES5
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:2,528,745-2,530,271
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

exact match: identifiers.org/ncbigene/388585
HomoloGene ID: 7755
cytogenetic location: 1p36.32
genomic start: 2460184
genomic end: 2530263

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Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.

HES5 regulates the development of the early brain by maintaining stem cell neural progenitors in the ventricular zone. HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia. Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.