HIC1
Sign in to saveAlso known as ZBTB29, ZNF901, hic-1, hypermethylated in cancer 1, HIC ZBTB transcriptional repressor 1
Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.
Gene data
HIC1- Name
- HIC ZBTB transcriptional repressor 1
- Type
- protein-coding
- Position
- 2,054,154–2,063,241 (+)
- Aliases
- ZBTB29, ZNF901, hic-1
- Ensembl
- ENSG00000177374
- RefSeq RNA
- NM_001098202.1, NM_006497.4
- RefSeq protein
- NP_001091672.1, NP_006488.2
This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010].
Gene Ontology
Biological process
negative regulation of transcription by RNA polymerase IInegative regulation of transcription by RNA polymerase IInegative regulation of transcription by RNA polymerase IIregulation of DNA-templated transcriptionregulation of transcription by RNA polymerase IIintrinsic apoptotic signaling pathway in response to DNA damageintrinsic apoptotic signaling pathway in response to DNA damageregulation of signal transduction
Molecular function
DNA-binding transcription factor activity, RNA polymerase II-specificDNA-binding transcription repressor activity, RNA polymerase II-specificDNA-binding transcription factor activityDNA-binding transcription factor activityprotein bindinghistone deacetylase bindingsequence-specific DNA bindingsequence-specific double-stranded DNA binding
Cellular component
Pathways
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4740
- exact match
- identifiers.org/ncbigene/3090
- genomic end
- 1962981
- genomic start
- 1957448
- cytogenetic location
- 17p13.3
Sources (3)
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Article
3 sectionsContents
- References
- Further reading
- External links
Hypermethylated in cancer 1 protein is a protein that in humans is encoded by the HIC1 gene.
==References==
Connections
Q180686
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human chromosome 17
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Ensembl genome database project
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homeobox
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PDX1
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protein
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Wikidata
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gene
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chromosome
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public domain
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digital object identifier
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bibcode
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human genome
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Q229883
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base pair
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Medical Subject Headings
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locus
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gene expression
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Online Mendelian Inheritance in Man
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United States National Library of Medicine
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