ICAM2

Also known as CD102, intercellular adhesion molecule 2

Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene, and the protein resulting from it.

Gene data

ICAM2

Name: intercellular adhesion molecule 2
Type: protein-coding
Position: 64,002,594–64,020,635 (−)
Aliases: CD102
Ensembl: ENSG00000108622
RefSeq RNA: NM_000873.4, NM_001099786.2, NM_001099787.2, NM_001099788.2, NM_001099789.2
RefSeq protein: NP_000864.2, NP_001093256.1, NP_001093257.1, NP_001093258.1, NP_001093259.1

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

Pathways

Cell adhesion molecules - Homo sapiens (human)Natural killer cell mediated cytotoxicity - Homo sapiens (human)Adaptive Immune System Extracellular matrix organization Innate Immune System Immune System Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions C-type lectin receptors (CLRs)CD209 (DC-SIGN) signaling

via MyGene.info

Wikidata facts

Image: Protein ICAM2 PDB 1zxq.png

Show 5 more facts

HomoloGene ID: 675
exact match: identifiers.org/ncbigene/3384
genomic end: 62097994
genomic start: 62079954
cytogenetic location: 17q23.3

Sources (4)

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Article

7 sections

Contents

Protein structure
Protein functions
Interactions
See also
References
Further reading
External links

Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene, and the protein resulting from it.

==Protein structure== The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.