CADM3

Also known as BIgR, IGSF4B, NECL1, Necl-1, TSLL1, synCAM3, cell adhesion molecule 3, CMT2FF

Cell adhesion molecule 3 is a protein that in humans is encoded by the CADM3 gene.

In the Vinony graph

Within Vinony's link graph, CADM3 is referenced by 70 other articles, and connects out to PubMed, Ensembl genome database project and protein.

It is catalogued under the topic Genes on human chromosome 1.

Its subject is documented across 6 Wikipedia language editions.

Gene data

CADM3

Name: cell adhesion molecule 3
Type: protein-coding
Position: 159,171,574–159,203,313 (+)
Aliases: BIgR, CMT2FF, IGSF4B, NECL1, Necl-1, TSLL1, synCAM3
Ensembl: ENSG00000162706
RefSeq RNA: NM_001127173.3, NM_001346510.2, NM_021189.5, XM_024448760.2, XM_054337944.1
RefSeq protein: NP_001120645.1, NP_001333439.1, NP_067012.1, XP_024304528.1, XP_054193919.1

The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016].

Gene Ontology

Biological process

homophilic cell-cell adhesion homophilic cell-cell adhesion homophilic cell-cell adhesion heterophilic cell-cell adhesion heterophilic cell-cell adhesion

Molecular function

protein binding protein homodimerization activity

Cellular component

plasma membrane plasma membrane plasma membrane plasma membrane cell-cell junction cell-cell junction presynaptic membrane presynaptic membrane

Pathways

Cell adhesion molecules - Homo sapiens (human)Cell-Cell communication Adherens junctions interactions Nectin/Necl trans heterodimerization Cell-cell junction organization Cell junction organization Splicing factor NOVA regulated synaptic proteins

via MyGene.info

Gene · Ensembl

cell adhesion molecule 3

Symbol: CADM3
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:159,171,574-159,203,313
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 10919
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/57863
chromosome: human chromosome 1
genomic start: 159141399
genomic end: 159173103
cytogenetic location: 1q23.2
expressed in: amygdala

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
External links
Further reading

Cell adhesion molecule 3 is a protein that in humans is encoded by the CADM3 gene.

IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005).

Excerpted from Wikipedia’s “CADM3” article, available under the CC BY-SA 4.0 licence.