IGSF8

Also known as CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL, immunoglobulin superfamily member 8

gene umano

In the Vinony graph

Within Vinony's link graph, IGSF8 is referenced by 359 other articles, and connects out to PubMed, Ensembl genome database project and CD1.

Vinony files it under Clusters of differentiation and Genes on human chromosome 1.

Its subject is documented across 5 Wikipedia language editions.

Gene data

IGSF8

Name: immunoglobulin superfamily member 8
Type: protein-coding
Position: 160,091,340–160,101,109 (−)
Aliases: CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL
Ensembl: ENSG00000162729
RefSeq RNA: NM_001206665.2, NM_001320247.2, NM_052868.6, XM_017002835.2, XM_017002836.2
RefSeq protein: NP_001193594.1, NP_001307176.1, NP_443100.1, XP_016858324.1, XP_016858325.1

This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011].