KLF14
Sign in to saveAlso known as BTEB5, Kruppel-like factor 14, Kruppel like factor 14
Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene. The corresponding Klf14 mouse gene is known as Sp6.
Gene data
KLF14- Name
- KLF transcription factor 14
- Type
- protein-coding
- Position
- 130,730,697–130,734,207 (−)
- Aliases
- BTEB5
- Ensembl
- ENSG00000266265
- RefSeq RNA
- NM_138693.4
- RefSeq protein
- NP_619638.2
This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 76469
- exact match
- identifiers.org/ncbigene/136259
- genomic start
- 130730697
- genomic end
- 130734207
- cytogenetic location
- 7q32.2
Sources (4)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Protein structure
- Clinical significance
- References
- External links
Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene. The corresponding Klf14 mouse gene is known as Sp6.
== Function == KLF14 is a member of the Krüppel-like factor family of transcription factors. It regulates the transcription of various genes, including TGFβRII (the type II receptor for TGFβ). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression.