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GeneQ18031990· pop 5· linked from 814 articles

KLF10

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Also known as EGR-alpha, EGRA, TIEG, TIEG1, Kruppel-like factor 10, Kruppel like factor 10

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.

In the Vinony graph

Vinony's link graph records 814 inbound references to KLF10, and connects out to PubMed, human chromosome 8 and homeobox.

It sits within the topics Genes on human chromosome 8 and Transcription factors.

Vinony links it to 5 Wikipedia language editions.

Gene data

KLF10

Name: KLF transcription factor 10
Type: protein-coding
Position: 102,648,781–102,655,729 (−)
Aliases: EGR-alpha, EGRA, TIEG, TIEG1
Ensembl: ENSG00000155090
RefSeq RNA: NM_001032282.4, NM_005655.4, NR_103759.2, NR_103760.2
RefSeq protein: NP_001027453.1, NP_005646.1

This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II cell-cell signaling circadian rhythm negative regulation of cell population proliferation cellular response to starvation cellular response to starvation regulation of circadian rhythm

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific core promoter sequence-specific DNA binding core promoter sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity

Cellular component

chromatin nucleus nucleus nucleus nucleus

Pathways

TGF-beta Signaling Pathway

via MyGene.info

Gene · Ensembl

KLF transcription factor 10

Symbol: KLF10
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:102,648,781-102,655,729
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 4135
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/7071
genomic end: 102655725
genomic start: 102648784
chromosome: human chromosome 8
cytogenetic location: 8q22.3
expressed in: Human penis

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

See also
References
Further reading
External links

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.

==See also== Kruppel-like factors

Excerpted from Wikipedia’s “KLF10” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 8 Transcription factors