KLF8

Also known as BKLF3, ZNF741, Kruppel-like factor 8, Kruppel like factor 8

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene. KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.

Gene data

KLF8

Name: KLF transcription factor 8
Type: protein-coding
Chromosome: X
Position: 56,232,356–56,291,531 (+)
Aliases: BKLF3, ZNF741
Ensembl: ENSG00000102349
RefSeq RNA: NM_001159296.2, NM_001324099.1, NM_001324100.1, NM_001324102.1, NM_001324104.1
RefSeq protein: NP_001152768.1, NP_001311028.1, NP_001311029.1, NP_001311031.1, NP_001311033.1

This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific double-stranded DNA binding

Cellular component

chromatin nucleus nucleus nucleoplasm

via MyGene.info

Research

143 papers

KLF8 is activated by TGF-β1 via Smad2 and contributes to ovarian cancer progression.Journal of cellular biochemistry · 2022
KLF8 promotes cancer stem cell-like phenotypes in osteosarcoma through miR-429-SOX2 signaling.Neoplasma · 2020
KLF8 Promotes the Survival of Lung Adenocarcinoma During Nutrient Deprivation by Regulating the Pentose Phosphate Pathway through SIRT2.Frontiers in bioscience (Landmark edition) · 2024
KLF8 promotes invasive outgrowth of breast cancer by inducing filopodium-like protrusions via CXCR4.American journal of translational research · 2022
miR-24-3p/KLF8 Signaling Axis Contributes to LUAD Metastasis by Regulating EMT.Journal of immunology research · 2020

via PubMed

Wikidata facts

Show 5 more facts

HomoloGene ID: 68549
exact match: identifiers.org/ncbigene/11279
genomic end: 56291531
genomic start: 56232356
cytogenetic location: Xp11.21

Sources (3)

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Contents

Interactions
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Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene. KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.

== Interactions ==