ليفوثيروكسين

Key facts

Drug.image

Levothyroxine 200.svg

Drug.image_class

skin-invert-image

Drug.image2

Levothyroxine-from-xtal-3D-bs-17.png

Drug.image_class2

bg-transparent

Drug.tradename

Synthroid, Levoxyl, others

Drug.MedlinePlus

a682461

Drug.DailyMedID

Levothyroxine

Drug.pregnancy_AU

A

Drug.routes_of_administration

By mouth, intravenous

Drug.ATC_prefix

H03

Drug.ATC_suffix

AA01

Drug.legal_AU

S4

Drug.legal_CA

Rx-only

Drug.legal_US

Rx only

Drug.bioavailability

40-80%

Drug.metabolism

Mainly in the liver, kidneys, brain, and muscles

Drug.elimination_half life

ca. 7 days (in hyperthyroidism 3–4 days, in hypothyroidism 9–10 days)

Drug.excretion

Feces and urine

via Wikipedia infobox

Chemical data

Formula

C15H11I4NO4

Molecular weight

776.87 g/mol

IUPAC name

(2S)-2-azaniumyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate

SMILES

C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)[O-])[NH3+]

InChIKey

XUIIKFGFIJCVMT-LBPRGKRZSA-N

XLogP

3

Polar surface area

97.2 Ų

H-bond donors

2

H-bond acceptors

4

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

First approval

1982

Admin. routes

oral, parenteral

Indications

diabetes mellitus, pregnancy, Graves disease, hypothyroidism

via ChEMBL · EBI

Wikidata facts

Subclass of

thyroxine

Mass

776.686699832

Has use

medication

via Wikidata · CC0