Structure via PubChem · Public domain (PubChem)
لووتیروکسین
Sign in to saveAlso known as levothyroxine sodium, Levothyroxin, 4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine, LT4, 3,3',5,5'-Tetraiodo-L-thyronine, Levothyroxine, O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine, T4
Levothyroxine, also known as -thyroxine, is a synthetic form of the thyroid hormone thyroxine (T4). It is used to treat thyroid hormone deficiency (hypothyroidism), including a severe form known as myxedema coma. It may also be used to treat and prevent certain types of thyroid tumors. It is not indicated for weight loss. Levothyroxine is taken orally (by mouth) or given by intravenous injection. Levothyroxine has a half-life of 7.5 days when taken daily, so about six weeks is required for it to reach a steady level in the blood.
Key facts
- Drug.image
- Levothyroxine 200.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Levothyroxine-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Synthroid, Levoxyl, others
- Drug.MedlinePlus
- a682461
- Drug.DailyMedID
- Levothyroxine
- Drug.pregnancy_AU
- A
- Drug.routes_of_administration
- By mouth, intravenous
- Drug.ATC_prefix
- H03
- Drug.ATC_suffix
- AA01
- Drug.legal_AU
- S4
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx only
- Drug.bioavailability
- 40-80%
- Drug.metabolism
- Mainly in the liver, kidneys, brain, and muscles
- Drug.elimination_half life
- ca. 7 days (in hyperthyroidism 3–4 days, in hypothyroidism 9–10 days)
- Drug.excretion
- Feces and urine
via Wikipedia infobox
Chemical data
- Formula
- C15H11I4NO4
- Molecular weight
- 776.87 g/mol
- IUPAC name
- (2S)-2-azaniumyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate
- SMILES
- C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)[O-])[NH3+]
- InChIKey
- XUIIKFGFIJCVMT-LBPRGKRZSA-N
- XLogP
- 3
- Polar surface area
- 97.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- thyroxine
- Mass
- 776.686699832
- Has use
- medication
Show 14 more facts
- medical condition treated
- goiter
- isomeric SMILES
- C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)O)N
- canonical SMILES
- C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N
- found in taxon
- Homo sapiens
- location of creation
- Bourgoin-Jallieu
- MCN code
- 3004.39.81
- chemical formula
- C₁₅H₁₁I₄NO₄
- melting point
- 232
- solubility
- 105
- half-life
- 1
- Commons category
- Levothyroxine
- subject has role
- primary metabolite
- significant drug interaction
- phenytoin
- legal status (medicine)
- boxed warning
Sources (8)
via Wikidata · CC0