LILRB1

Name

leukocyte immunoglobulin like receptor B1

Type

protein-coding

Position

54,616,309–54,638,022 (+)

Aliases

CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB

Ensembl

ENSG00000277134

RefSeq RNA

NM_001081637.3, NM_001081638.4, NM_001081639.4, NM_001278398.2, NM_001278399.2

RefSeq protein

NP_001075106.2, NP_001075107.2, NP_001075108.2, NP_001265327.2, NP_001265328.2

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

leukocyte immunoglobulin like receptor B1

Symbol

LILRB1

Biotype

Protein coding

Organism

Homo sapiens

Location

19:54,616,309-54,638,022

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein LILRB1 PDB 1g0x.png

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