lomustine
Sign in to saveLomustine (INN; abbreviated as CCNU; original brand name CeeNU, now marketed as Gleostine) is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a highly lipid-soluble drug, thus it crosses the blood–brain barrier. This property makes it ideal for treating brain tumors, which is its primary use, although it is also used to treat Hodgkin lymphoma as a second-line option. It has also been used in veterinary practice as a treatment for cancers in cats and dogs.
Key facts
- Drug.N
- 3
- Drug.O
- 2
- Drug.H
- 16
- Drug.Cl
- 1
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 462093427
- Drug.IUPAC_name
- N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea
- Drug.image
- Lomustine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Lomustine ball-and-stick model.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 175
- Drug.tradename
- Gleostine, CCNU, CeeNu, CuuNu
- Drug.MedlinePlus
- a682207
- Drug.pregnancy_US
- D
- Drug.legal_CA
- Rx-only
via Wikipedia infobox
Article
26 sectionsContents
- Medical uses
- Chemotherapy in human medicine
- Pregnant patients
- Breastfeeding patients
- Pediatric patients
- Geriatric patients
- Chemotherapy in veterinary medicine
- Administration
- Side effects
- Safety
- Toxicities
- Secondary malignancies
- Delayed myelosupression
- Overdose risk
- Drug interactions
- Manufacturing
- Pharmacology
- Mechanism of action
- History
- FDA approval
- Society and culture
- Pricing controversies
- Research
- Clinical trials
- References
- External links
Lomustine (INN; abbreviated as CCNU; original brand name CeeNU, now marketed as Gleostine) is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a highly lipid-soluble drug, thus it crosses the blood–brain barrier. This property makes it ideal for treating brain tumors, which is its primary use, although it is also used to treat Hodgkin lymphoma as a second-line option. It has also been used in veterinary practice as a treatment for cancers in cats and dogs.
Lomustine is a bifunctional alkylating agent, alkylates both DNA and RNA, has the ability to created interstrand cross-links (ICLs) in DNA. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins. Lomustine is cell-cycle nonspecific.