Lomustine

Also known as CCNU, CeeNU®, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea, 1-(2-chloroethyl)-3-cyclohexylnitrosourea, CINU, cyclohexyl chloroethyl nitrosourea, chloroethylcyclohexylnitrosourea, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea

Lomustine (INN; abbreviated as CCNU; original brand name CeeNU, now marketed as Gleostine) is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a highly lipid-soluble drug, thus it crosses the blood–brain barrier. This property makes it ideal for treating brain tumors, which is its primary use, although it is also used to treat Hodgkin lymphoma as a second-line option. It has also been used in veterinary practice as a treatment for cancers in cats and dogs.