Structure via PubChem · Public domain (PubChem)
lomustine
Sign in to saveAlso known as CCNU, CeeNU®, N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea, 1-(2-chloroethyl)-3-cyclohexylnitrosourea, CINU, cyclohexyl chloroethyl nitrosourea, chloroethylcyclohexylnitrosourea, 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
chemische verbinding
Key facts
- Drug.N
- 3
- Drug.O
- 2
- Drug.H
- 16
- Drug.Cl
- 1
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 462093427
- Drug.IUPAC_name
- N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea
- Drug.image
- Lomustine.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200
- Drug.image2
- Lomustine ball-and-stick model.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 175
- Drug.tradename
- Gleostine, CCNU, CeeNu, CuuNu
- Drug.MedlinePlus
- a682207
- Drug.pregnancy_US
- D
- Drug.legal_CA
- Rx-only
via Wikipedia infobox
Chemical data
- Formula
- C9H16ClN3O2
- Molecular weight
- 233.69 g/mol
- IUPAC name
- 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
- SMILES
- C1CCC(CC1)NC(=O)N(CCCl)N=O
- InChIKey
- GQYIWUVLTXOXAJ-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 61.8 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
3,011 papers- Lomustine and Bevacizumab in Progressive Glioblastoma.The New England journal of medicine · 2017
- Lomustine, methotrexate and cytarabine chemotherapy as a rescue treatment for feline lymphoma.Journal of feline medicine and surgery · 2021
- Regorafenib compared with lomustine in patients with relapsed glioblastoma (REGOMA): a multicentre, open-label, randomised, controlled, phase 2 trial.The Lancet. Oncology · 2019
- How did lomustine become standard of care in recurrent glioblastoma?Cancer treatment reviews · 2020
- Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial.The Lancet. Oncology · 2014
via PubMed