mequitazine

Also known as Kitazemin, Mequitazina, Mequitazinum

Mequitazine (trade name Primalan) is an H1 antagonist and anticholinergic of the phenothiazine chemical class. It is used to treat allergies and rhinitis.

Research

153 papers

Development of radioiodine-labeled mequitazine for evaluation of hepatic CYP2D activity.Frontiers in pharmacology · 2024
[Efficiency of mequitazine in the treatment of allergic rhinitis and chronic urticaria in children. A bibliographic systematic review].Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) · 2008
Second-Generation H(1)-Receptor Antagonists, Mequitazine, Azelastine and Desloratadine Activate Caspase-8, Caspase-3, and Gasdermin E and Induce Cell Death Showing Pyroptotic-Like Features in Macrophages at Excessively High Concentrations.Biological & pharmaceutical bulletin · 2025
Photodegradation and photostability-indication of mequitazine.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2009
Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.The Journal of pharmacology and experimental therapeutics · 1998

via PubMed

Wikidata facts

Mass: 322.15037

Show 4 more facts

canonical SMILES: C1CN2CCC1C(C2)CN3C4=CC=CC=C4SC5=CC=CC=C53
chemical formula: C₂₀H₂₂N₂S
defined daily dose: 10
Commons category: Mequitazine

Sources (3)

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Article

8 sections

Contents

Contraindications
Special precautions
Adverse reactions
Drug interactions
Synthesis
References
Further reading
External links

Mequitazine (trade name Primalan) is an H1 antagonist and anticholinergic of the phenothiazine chemical class. It is used to treat allergies and rhinitis.

It was patented in 1969 and came into medical use in 1976.