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oxaflozane
Sign in to saveOxaflozane (INN; brand name Conflictan) is an antidepressant and anxiolytic drug that was introduced by Solvay in France in 1982 for the treatment of depression but has since been discontinued. It is a prodrug of flumexadol (N-dealkyloxaflozane; 2-(3-trifluoromethylphenyl)morpholine; CERM-1841 or 1841-CERM), which is reported to act as an agonist of the serotonin 5-HT1A (pKi = 7.1) and 5-HT2C (pKi = 7.5) receptors and, to a much lesser extent, of the 5-HT2A (pKi = 6.0) receptor. In addition to its serotonergic properties, oxaflozane may also produce anticholinergic side effects at high doses,
Chemical data
- Formula
- C14H18F3NO
- Molecular weight
- 273.29 g/mol
- IUPAC name
- 4-propan-2-yl-2-[3-(trifluoromethyl)phenyl]morpholine
- SMILES
- CC(C)N1CCOC(C1)C2=CC(=CC=C2)C(F)(F)F
- InChIKey
- FVYUQFQCEOZYHZ-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 12.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- major depressive disorder
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 273.134
Show 3 more facts
- chemical formula
- C₁₄H₁₈F₃NO
- canonical SMILES
- CC(C)N1CCOC(C1)C2=CC(=CC=C2)C(F)(F)F
- Commons category
- Oxaflozane
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- Further reading
Oxaflozane (INN; brand name Conflictan) is an antidepressant and anxiolytic drug that was introduced by Solvay in France in 1982 for the treatment of depression but has since been discontinued. It is a prodrug of flumexadol (N-dealkyloxaflozane; 2-(3-trifluoromethylphenyl)morpholine; CERM-1841 or 1841-CERM), which is reported to act as an agonist of the serotonin 5-HT1A (pKi = 7.1) and 5-HT2C (pKi = 7.5) receptors and, to a much lesser extent, of the 5-HT2A (pKi = 6.0) receptor. In addition to its serotonergic properties, oxaflozane may also produce anticholinergic side effects at high doses, namely in overdose.
==See also== Fluminorex Fludorex Fenfluramine TFMPP Befiradol
Excerpted from Wikipedia’s “oxaflozane” article, available under the CC BY-SA 4.0 licence.