Structure via PubChem · Public domain (PubChem)
pinacidil
Sign in to saveAlso known as Pindac®, pinacidil anhydrous
Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles. It reduces blood pressure and peripheral resistance and produces fluid retention.
Chemical data
- Formula
- C13H19N5
- Molecular weight
- 245.32 g/mol
- IUPAC name
- 1-cyano-2-(3,3-dimethylbutan-2-yl)-3-pyridin-4-ylguanidine
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1989
- Admin. routes
- oral
via ChEMBL · EBI
Research
1,548 papers- Pinacidil ameliorates cardiac microvascular ischemia-reperfusion injury by inhibiting chaperone-mediated autophagy of calreticulin.Basic research in cardiology · 2024
- Pinacidil. Preclinical investigations.Drugs · 1988
- Pinacidil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the treatment of hypertension.Drugs · 1990
- Repositioning pinacidil and its anticonvulsant and anxiolytic properties in murine models.Scientific reports · 2024
- Cromakalim, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle.General pharmacology · 1989
via PubMed
Wikidata facts
- Mass
- 245.164046
Show 5 more facts
- canonical SMILES
- CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1
- isomeric SMILES
- CC(N/C(=N\C#N)/NC1=CC=NC=C1)C(C)(C)C
- Commons category
- Pinacidil
- defined daily dose
- 50
- chemical formula
- C₁₃H₁₉N₅
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Synthesis
- References
- External links
Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles. It reduces blood pressure and peripheral resistance and produces fluid retention.
Pinacidil has been associated with development of hypertrichosis in 2 to 13% of patients.
Gallery (2)
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