SAE1
Sign in to saveAlso known as AOS1, HSPC140, SUA1, UBLE1A, SUMO1 activating enzyme subunit 1
SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.
In the Vinony graph
Vinony's link graph records 112 inbound references to SAE1, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 19.
Vinony links it to 6 Wikipedia language editions.
Gene data
SAE1- Name
- SUMO1 activating enzyme subunit 1
- Type
- protein-coding
- Position
- 47,113,274–47,210,636 (+)
- Aliases
- AOS1, HSPC140, SUA1, UBLE1A
- Ensembl
- ENSG00000142230
- RefSeq RNA
- NM_001145713.2, NM_001145714.2, NM_005500.3, NR_027280.2
- RefSeq protein
- NP_001139185.1, NP_001139186.1, NP_005491.1
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SUMO1 activating enzyme subunit 1
- Symbol
- SAE1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:47,113,274-47,210,636
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SAE1 PDB 1y8q.png
Show 9 more facts
- HomoloGene ID
- 4019
- genetic association
- multiple sclerosis
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10055
- genomic end
- 47713886
- genomic start
- 47616531
- chromosome
- human chromosome 19
- cytogenetic location
- 19q13.32
- expressed in
- smooth muscle tissue
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Interactions
- References
- Further reading
- External links
SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.
== Interactions ==
Excerpted from Wikipedia’s “SAE1” article, available under the CC BY-SA 4.0 licence.