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GeneQ18034988· pop 6· linked from 112 articles

Also known as AOS1, HSPC140, SUA1, UBLE1A, SUMO1 activating enzyme subunit 1

SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.

Gene data

SAE1
Name
SUMO1 activating enzyme subunit 1
Type
protein-coding
Aliases
AOS1, HSPC140, SUA1, UBLE1A

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010].

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Wikidata facts

Image
Protein SAE1 PDB 1y8q.png
Show 5 more facts
HomoloGene ID
4019
genomic end
47713886
genomic start
47616531
cytogenetic location
19q13.32
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  • Interactions
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SUMO-activating enzyme subunit 1 is a protein that in humans is encoded by the SAE1 gene.

== Interactions ==

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