Satavaptan (INN; developmental code name SR121463, former tentative brand name Aquilda) is a vasopressin V2 receptor antagonist which was investigation by Sanofi-Aventis and was under development for the treatment of hyponatremia. It was also being studied for the treatment of ascites. Development was discontinued in 2009.
via PubMed
{{Infobox drug | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 455169440 | drug_name = Satavaptan | IUPAC_name = N-(tert-butyl)-4-{[(1s,4s)-5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl]sulfonyl}-3-methoxybenzamide | image = Satavaptan structure.svg | image_class = skin-invert-image | width = 200 | tradename = | legal_status = | routes_of_administration = | CAS_number_Ref = | CAS_number = 185913-78-4 | ATC_prefix = none | PubChem = 9810773 | DrugBank_Ref = | UNII_Ref = | synonyms = SR121463 | UNII = AJS8S3P31H | C = 33 | H = 45 | N = 3 | O = 8 | S = 1 | ChemSpiderID_Ref = | ChemSpiderID = 32699105 | smiles = C1COCCN1CCO[C@H]2CC[C@](CC2)3c4cc(OCC)ccc4N(C3=O)S(=O)(=O)c5ccc(cc5OC)C(=O)NC(C)(C)C | StdInChI_Ref = | StdInChI = 1S/C33H45N3O8S/c1-6-43-25-8-9-27-26(22-25)33(13-11-24(12-14-33)44-20-17-35-15-18-42-19-16-35)31(38)36(27)45(39,40)29-10-7-23(21-28(29)41-5)30(37)34-32(2,3)4/h7-10,21-22,24H,6,11-20H2,1-5H3,(H,34,37)/t24-,33+ | StdInChIKey_Ref = | StdInChIKey = QKXJWFOKVQWEDZ-VCCCEUOBSA-N }}
Satavaptan (INN; developmental code name SR121463, former tentative brand name Aquilda) is a vasopressin V2 receptor antagonist which was investigation by Sanofi-Aventis and was under development for the treatment of hyponatremia. It was also being studied for the treatment of ascites. Development was discontinued in 2009.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).