SOX17
Sign in to saveAlso known as VUR3, SRY-box 17, SRY-box transcription factor 17
SRY-box 17 is a protein that in humans is encoded by the SOX17 gene.
Gene data
SOX17- Name
- SRY-box transcription factor 17
- Type
- protein-coding
- Aliases
- PPH7, VUR3
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008].
via MyGene.info
Wikidata facts
- Image
- SOX17.png
Show 5 more facts
- HomoloGene ID
- 7948
- exact match
- identifiers.org/ncbigene/64321
- genomic end
- 54460892
- genomic start
- 55370495
- cytogenetic location
- 8q11.23
Sources (4)
via Wikidata · CC0
~2 min read
Article
4 sectionsContents
- Regulation at the human ''SOX17'' locus
- Function in development
- References
- Further reading
SRY-box 17 is a protein that in humans is encoded by the SOX17 gene.
== Regulation at the human SOX17 locus == The gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, located on Chromosome 8 q11.23. Its gene body is isolated within a CTCF loop domain. Approximately 230 kb upstream of SOX17 it has been identified a tissue specific differentially (hypo-)methylated region (DMR), which consists of SOX17 regulatory elements. The DMR in particular bears the most distal definitive endoderm-specific enhancer at the SOX17 locus. SOX17 itself has recently been defined as so called topologically insulated gene (TIG). TIGs per definition are single protein coding genes (PCGs) within CTCF loop domains, that are mainly enriched in developmental regulators and suggested to be very tightly controlled via their 3D loop-domain architecture.