trandolapril

Key facts

Drug.Watchedfields

changed

Drug.verifiedrevid

470612121

Drug.IUPAC_name

(2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid

Drug.image

Trandolapril structure.svg

Drug.image_class

skin-invert-image

Drug.width2

222

Drug.tradename

Mavik, others

Drug.MedlinePlus

a697010

Drug.pregnancy_US

D

Drug.legal_status

Rx-only

Drug.routes_of_administration

By mouth

Drug.protein_bound

Trandolapril 80%(independent of concentration)Trandolaprilat 65 to 94%(concentration-dependent)

Drug.metabolism

Liver

Drug.elimination_half life

6 hours (trandolapril)10 hours (trandolaprilat)

Drug.excretion

Fecal and Kidney

Drug.IUPHAR_ligand

6453

Drug.CAS_number

87679-37-6

Drug.ATC_prefix

C09

via Wikipedia infobox

Chemical data

Formula

C24H34N2O5

Molecular weight

430.5 g/mol

IUPAC name

(2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid

SMILES

CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCCC[C@@H]3C[C@H]2C(=O)O

InChIKey

VXFJYXUZANRPDJ-WTNASJBWSA-N

XLogP

2

Polar surface area

95.9 Ų

H-bond donors

2

H-bond acceptors

6

Formal charge

0

via PubChem

• Trandolapril. An update of its pharmacology and therapeutic use in cardiovascular disorders.Drugs · 1998
• Trandolapril: a clinical profile.American journal of hypertension · 1995
• Trandolapril/verapamil combination in hypertensive diabetic patients.Vascular health and risk management · 2007
• Trandolapril/verapamil sustained release: a review of its use in the treatment of essential hypertension.Drugs · 2005
• Update on the use of trandolapril in the management of cardiovascular disorders.Vascular health and risk management · 2008

via PubMed