trandolapril
Sign in to saveTrandolapril is an ACE inhibitor used to treat high blood pressure. It may also be used to treat other conditions. It is similar in structure to another ramipril but has a cyclohexane group. It is a prodrug that must be metabolized into its active form. It has a longer half-life when compared to other agents in this class.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 470612121
- Drug.IUPAC_name
- (2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid
- Drug.image
- Trandolapril structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width2
- 222
- Drug.tradename
- Mavik, others
- Drug.MedlinePlus
- a697010
- Drug.pregnancy_US
- D
- Drug.legal_status
- Rx-only
- Drug.routes_of_administration
- By mouth
- Drug.protein_bound
- Trandolapril 80%(independent of concentration)Trandolaprilat 65 to 94%(concentration-dependent)
- Drug.metabolism
- Liver
- Drug.elimination_half life
- 6 hours (trandolapril)10 hours (trandolaprilat)
- Drug.excretion
- Fecal and Kidney
- Drug.IUPHAR_ligand
- 6453
- Drug.CAS_number
- 87679-37-6
- Drug.ATC_prefix
- C09
via Wikipedia infobox
Research
754 papers- Trandolapril. An update of its pharmacology and therapeutic use in cardiovascular disorders.Drugs · 1998
- Trandolapril: a clinical profile.American journal of hypertension · 1995
- Trandolapril/verapamil combination in hypertensive diabetic patients.Vascular health and risk management · 2007
- Trandolapril/verapamil sustained release: a review of its use in the treatment of essential hypertension.Drugs · 2005
- Update on the use of trandolapril in the management of cardiovascular disorders.Vascular health and risk management · 2008
via PubMed
Article
9 sectionsContents
- Side effects
- Possible drug interactions
- Contraindications and precautions
- Pregnancy and lactation
- Additional effects
- Pharmacology
- Mode of action
- References
- External links
{{Infobox drug | Watchedfields = changed | verifiedrevid = 470612121 | IUPAC_name = (2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid | image = Trandolapril structure.svg | image_class = skin-invert-image | width2 = 222
| tradename = Mavik, others | Drugs.com = | MedlinePlus = a697010 | pregnancy_US = D | legal_status = Rx-only | routes_of_administration = By mouth