zolazepam

Zolazepam (Flupyrazapon) is a pyrazolodiazepinone derivative structurally related to the benzodiazepine drugs, which is used as an anaesthetic for a wide range of animals in veterinary medicine. Zolazepam is usually administered in combination with other drugs such as the NMDA antagonist tiletamine or the α2 adrenergic receptor agonist xylazine, depending on what purpose it is being used for. It has 5-10 times the potency of diazepam.

Chemical data

Formula: C15H15FN4O
Molecular weight: 286.3 g/mol
IUPAC name: 4-(2-fluorophenyl)-1,3,8-trimethyl-6H-pyrazolo[5,4-e][1,4]diazepin-7-one

via PubChem

Research

523 papers

Tiletamine-Zolazepam Use in Exotic Pets and Wildlife Anesthesia: A Narrative Review Towards Practical Guidelines.Animals : an open access journal from MDPI · 2026
Dissociative anaesthesia in dogs and cats with use of tiletamine and zolazepam combination. What we already know about it.Polish journal of veterinary sciences · 2021
TILETAMINE-ZOLAZEPAM-XYLAZINE ANESTHESIA IN EX SITU BLACK-HANDED SPIDER MONKEYS (ATELES GEOFFROYI SSP.).Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians · 2024
Tiletamine-Zolazepam for Total Intravenous Anesthesia in Sheep.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025

Article

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Contents

References

Zolazepam was developed by Horace A. de Wald and Donald E. Butler for Parke-Davis and was the result of a very detailed analysis of the benzodiazepine structure ( filed in 1969).