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afloqualone
Sign in to saveAfloqualone (Arofuto) is a quinazolinone family GABAergic drug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku. It has sedative and muscle-relaxant effects resulting from its agonist activity at the β subtype of the GABAa receptor and has had some clinical use, although it causes photosensitization as a side-effect that can cause skin problems such as dermatitis.
Chemical data
- Formula
- C16H14FN3O
- Molecular weight
- 283.3 g/mol
- IUPAC name
- 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
37 papers- Coma and seizure caused by an afloqualone overdose.Pediatrics international : official journal of the Japan Pediatric Society · 2019
- Accidental afloqualone intoxication in two dogs.The Journal of veterinary medical science · 2018
- Afloqualone photosensitivity: immunogenicity of afloqualone-photomodified epidermal cells.Photochemistry and photobiology · 1994
- Afloqualone phototoxicity--photosensitized lipid peroxidative potency and its biological significance.The Tokai journal of experimental and clinical medicine · 1989
- Comparison of the myotonolytic activity of tizanidine, eperisone and afloqualone in mouse and rabbit.The Journal of international medical research · 1989
via PubMed
Wikidata facts
- Mass
- 283.112
Show 3 more facts
- chemical formula
- C₁₆H₁₄FN₃O
- canonical SMILES
- CC1=CC=CC=C1N2C(=NC3=C(C2=O)C=C(C=C3)N)CF
- Commons category
- Afloqualone
Sources (2)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- See also
- References
Afloqualone (Arofuto) is a quinazolinone family GABAergic drug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku. It has sedative and muscle-relaxant effects resulting from its agonist activity at the β subtype of the GABAa receptor and has had some clinical use, although it causes photosensitization as a side-effect that can cause skin problems such as dermatitis.
== See also == Diproqualone Etaqualone Methylmethaqualone Mecloqualone Mebroqualone Cloroqualone Nitromethaqualone