Structure via PubChem · Public domain (PubChem)
alclofenac
Sign in to saveAlso known as 3-Chloro-4-(2-propenyloxy)benzeneacetic acid, [4-(allyloxy)-3-chlorophenyl]acetic acid, Alclofenacum, Alclophenac, Alclofénac, Alclofenaco, (4-Allyloxy-3-chlorphenyl)essigsäure
Alclofenac is a non-steroidal anti-inflammatory drug (NSAID) of the arylacetic acid class, that was mainly used for rheumatic disorders, such as rheumatoid arthritis, degenerative joint disease, and ankylosing spondylitis. It exhibits anti‑inflammatory, analgesic, and antipyretic properties primarily through reversible inhibition of cyclooxygenase (COX) enzymes and subsequent suppression of prostaglandin synthesis. However, it has largely fallen into disuse in favour of safer alternatives such as aceclofenac and was even withdrawn from multiple countries’ markets due to concerns about some of
Chemical data
- Formula
- C11H11ClO3
- Molecular weight
- 226.65 g/mol
- IUPAC name
- 2-(3-chloro-4-prop-2-enoxyphenyl)acetic acid
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- rheumatic disease
via ChEMBL · EBI
Research
107 papers- Clinical studies on alclofenac in the treatment of rheumatic diseases: a drug in question.Current medical research and opinion · 1975
- The chemical and biological background to alclofenac.Current medical research and opinion · 1975
- A review of possible mechanisms of action of the antirheumatic drug, alclofenac.Current medical research and opinion · 1975
- Alclofenac (Prinalgin).Drug and therapeutics bulletin · 1972
- Adverse reactions to alclofenac.Current medical research and opinion · 1975
via PubMed
Wikidata facts
- Subclass of
- carboxylic acid
- Mass
- 226.04
Show 4 more facts
- chemical formula
- C₁₁H₁₁ClO₃
- canonical SMILES
- C=CCOC1=C(C=C(C=C1)CC(=O)O)Cl
- World Health Organisation international non-proprietary name
- alclofenac
- subject has role
- non-steroidal anti-inflammatory drug
Sources (2)
via Wikidata · CC0
~15 min read
Encyclopedic overview
13 sectionsContents
- History
- Medical uses
- Contraindications
- Side effects
- Skin reactions and vasculitis
- Pharmacology
- Pharmacokinetics
- Mechanism of action
- Toxicity
- Chemistry
- Synthesis
- Structure and reactivity
- References
Alclofenac is a non-steroidal anti-inflammatory drug (NSAID) of the arylacetic acid class, that was mainly used for rheumatic disorders, such as rheumatoid arthritis, degenerative joint disease, and ankylosing spondylitis. It exhibits anti‑inflammatory, analgesic, and antipyretic properties primarily through reversible inhibition of cyclooxygenase (COX) enzymes and subsequent suppression of prostaglandin synthesis. However, it has largely fallen into disuse in favour of safer alternatives such as aceclofenac and was even withdrawn from multiple countries’ markets due to concerns about some of its side effects.
It can be taken orally or rectally. Administration by injection is difficult, since alclofenac is poorly soluble in physiological liquids. However, its lysine salt is water soluble and can be given by injection.
Excerpted from Wikipedia’s “alclofenac” article, available under the CC BY-SA 4.0 licence.
Gallery (4)
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via Wikidata sitelinks · CC0