alclofenac
Alclofenac is a non-steroidal anti-inflammatory drug (NSAID) of the arylacetic acid class, that was mainly used for rheumatic disorders, such as rheumatoid arthritis, degenerative joint disease, and ankylosing spondylitis. It exhibits anti‑inflammatory, analgesic, and antipyretic properties primarily through reversible inhibition of cyclooxygenase (COX) enzymes and subsequent suppression of prostaglandin synthesis. However, it has largely fallen into disuse in favour of safer alternatives such as aceclofenac and was even withdrawn from multiple countries’ markets due to concerns about some of
Chemical data
- Formula
- C11H11ClO3
- Molecular weight
- 226.65 g/mol
- IUPAC name
- 2-(3-chloro-4-prop-2-enoxyphenyl)acetic acid
via PubChem
Research
107 papers- Clinical studies on alclofenac in the treatment of rheumatic diseases: a drug in question.Current medical research and opinion · 1975
- The chemical and biological background to alclofenac.Current medical research and opinion · 1975
- A review of possible mechanisms of action of the antirheumatic drug, alclofenac.Current medical research and opinion · 1975
- Alclofenac (Prinalgin).Drug and therapeutics bulletin · 1972
- Adverse reactions to alclofenac.Current medical research and opinion · 1975
Article
13 sectionsContents
- History
- Medical uses
- Contraindications
- Side effects
- Skin reactions and vasculitis
- Pharmacology
- Pharmacokinetics
- Mechanism of action
- Toxicity
- Chemistry
- Synthesis
- Structure and reactivity
- References
Alclofenac is a non-steroidal anti-inflammatory drug (NSAID) of the arylacetic acid class, that was mainly used for rheumatic disorders, such as rheumatoid arthritis, degenerative joint disease, and ankylosing spondylitis. It exhibits anti‑inflammatory, analgesic, and antipyretic properties primarily through reversible inhibition of cyclooxygenase (COX) enzymes and subsequent suppression of prostaglandin synthesis. However, it has largely fallen into disuse in favour of safer alternatives such as aceclofenac and was even withdrawn from multiple countries’ markets due to concerns about some of its side effects.
It can be taken orally or rectally. Administration by injection is difficult, since alclofenac is poorly soluble in physiological liquids. However, its lysine salt is water soluble and can be given by injection.