Structure via PubChem · Public domain (PubChem)
bufuralol
Sign in to saveAlso known as Bufuralolum
Bufuralol is a potent beta-adrenoceptor antagonist with partial agonist activity. It is metabolized by CYP2D6.
In the Vinony graph
Within Vinony's link graph, bufuralol is referenced by 560 other articles, and connects out to beta blocker, medication and circulatory system.
Vinony files it under Benzofuranethanamines, Beta blockers and Chembox image size set.
Its subject is documented across 6 Wikipedia language editions.
Chemical data
- Formula
- C16H23NO2
- Molecular weight
- 261.36 g/mol
- IUPAC name
- 2-(tert-butylamino)-1-(7-ethyl-1-benzofuran-2-yl)ethanol
- SMILES
- CCC1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O
- InChIKey
- SSEBTPPFLLCUMN-UHFFFAOYSA-N
- XLogP
- 3.5
- Polar surface area
- 45.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
446 papers- Stereoselectivity in the oxidation of bufuralol, a chiral substrate, by human cytochrome P450s.Chirality · 2003
- (+)-bufuralol 1'-hydroxylation activity in human and rhesus monkey intestine and liver.Biochemical pharmacology · 1995
- Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6.Methods in enzymology · 1991
- Bufuralol 1'-hydroxylase activity of the rat. Strain differences and the effects of inhibitors.Biochemical pharmacology · 1986
- Bufuralol metabolism in human liver: a sensitive probe for the debrisoquine-type polymorphism of drug oxidation.European journal of clinical investigation · 1984
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 261.173
Show 3 more facts
- chemical formula
- C₁₆H₂₃NO₂
- canonical SMILES
- CCC1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O
- subject has role
- beta blocker
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Bufuralol is a potent beta-adrenoceptor antagonist with partial agonist activity. It is metabolized by CYP2D6.
Most beta blockers are aryloxypropanolamine-based. In this rare exception, the benzofuran oxygen is part of a ring rather than derived from the epichlorohydrin precursor.
Excerpted from Wikipedia’s “bufuralol” article, available under the CC BY-SA 4.0 licence.