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GeneQ5173299· pop 7· linked from 494 articles

CRHR2

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Also known as CRF-RB, CRF2, CRFR2, HM-CRF, corticotropin releasing hormone receptor 2

protein-coding gene in the species Homo sapiens

In the Vinony graph

Vinony's link graph records 494 inbound references to CRHR2, and connects out to PubMed, Ensembl genome database project and protein.

Vinony files it under Corticotropin-releasing hormone, Genes on human chromosome 7 and G protein-coupled receptors.

Vinony links it to 6 Wikipedia language editions.

Gene data

CRHR2

Name: corticotropin releasing hormone receptor 2
Type: protein-coding
Position: 30,651,444–30,700,129 (−)
Aliases: CRF-RB, CRF2, CRFR2, HM-CRF
Ensembl: ENSG00000106113
RefSeq RNA: NM_001202475.1, NM_001202481.1, NM_001202482.2, NM_001202483.2, NM_001883.5
RefSeq protein: NP_001189404.1, NP_001189410.1, NP_001189411.1, NP_001189412.1, NP_001874.2

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011].

Gene Ontology

Biological process

cell surface receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway hormone-mediated signaling pathway positive regulation of corticotropin secretion general adaptation syndrome

Molecular function

transmembrane signaling receptor activity G protein-coupled receptor activity protein binding G protein-coupled peptide receptor activity G protein-coupled peptide receptor activity corticotrophin-releasing factor receptor activity corticotrophin-releasing factor receptor activity corticotrophin-releasing factor receptor activity

Cellular component

plasma membrane plasma membrane plasma membrane plasma membrane plasma membrane membrane dendrite axon terminus

Pathways

Neuroactive ligand-receptor interaction - Homo sapiens (human)Cushing syndrome - Homo sapiens (human)Signal Transduction Peptide hormone metabolism Signaling by GPCR Class B/2 (Secretin family receptors)GPCR downstream signalling Metabolism of proteins G alpha (s) signalling events Synthesis, secretion, and deacylation of Ghrelin

via MyGene.info

Gene · Ensembl

corticotropin releasing hormone receptor 2

Symbol: CRHR2
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:30,651,444-30,700,129
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 9 more facts

found in taxon: Homo sapiens
HomoloGene ID: 55612
genetic association: type 2 diabetes
exact match: identifiers.org/ncbigene/1395
genomic end: 30739745
genomic start: 30651942
chromosome: human chromosome 7
cytogenetic location: 7p14.3
expressed in: prefrontal cortex

Sources (5)

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Available in 6 languages

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Categories

Corticotropin-releasing hormone Genes on human chromosome 7 G protein-coupled receptors