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GeneQ18037195· pop 6· linked from 813 articles

HEY1

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Also known as BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1, hes related family bHLH transcription factor with YRPW motif 1

Hairy/enhancer-of-split related with YRPW motif protein 1 is a protein that in humans is encoded by the HEY1 gene.

Gene data

HEY1

Name: hes related family bHLH transcription factor with YRPW motif 1
Type: protein-coding
Position: 79,762,371–79,767,857 (−)
Aliases: BHLHb31, CHF2, HERP2, HESR1, HRT-1, NERP2, OAF1, hHRT1
Ensembl: ENSG00000164683
RefSeq RNA: NM_001040708.2, NM_001282851.2, NM_012258.4
RefSeq protein: NP_001035798.1, NP_001269780.1, NP_036390.3

This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II angiogenesis cardiac conduction system development aortic valve morphogenesis pulmonary valve morphogenesis

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific

Cellular component

chromatin nucleus nucleus nucleus nucleoplasm nucleoplasm cytoplasm

Pathways

Notch signaling pathway - Homo sapiens (human)Human papillomavirus infection - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Breast cancer - Homo sapiens (human)Developmental Biology Signaling by NOTCH Signaling by NOTCH Signal Transduction Signal Transduction Disease

via MyGene.info

Gene · Ensembl

hes related family bHLH transcription factor with YRPW motif 1

Symbol: HEY1
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:79,762,371-79,767,857
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein HEY1 PDB 2db7.png

Show 5 more facts

HomoloGene ID: 7756
exact match: identifiers.org/ncbigene/23462
genomic end: 79767857
genomic start: 79762371
cytogenetic location: 8q21.13

Sources (4)

via Wikidata · CC0

~1 min read

Article

5 sections

Contents

Function
Role in disease
References
Further reading
External links

Hairy/enhancer-of-split related with YRPW motif protein 1 is a protein that in humans is encoded by the HEY1 gene.

== Function ==

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Categories

Genes on human chromosome 8 Transcription factors