Structure via PubChem · Public domain (PubChem)
ایپریندول
Sign in to saveAlso known as pramindole, 3-(6,7,8,9,10,11-hexahydro- 5H-cycloocta[b]indol-5-yl)-N,N-dimethylpropan-1-amine, Prondol, Galatur, Tertran
Iprindole, sold under the brand names Prondol, Galatur, and Tertran, is an atypical tricyclic antidepressant (TCA) that has been used in the United Kingdom and Ireland for the treatment of depression but appears to no longer be marketed. It was developed by Wyeth and was marketed in 1967. The drug has been described by some as the first "second-generation" antidepressant to be introduced. However, it was very little-used compared to other TCAs, with the number of prescriptions dispensed only in the thousands.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 439569389
- Drug.IUPAC_name
- 3-(6,7,8,9,10,11-hexahydro-5H-cycloocta[b]indol-5-yl)-N,N-dimethylpropan-1-amine
- Drug.image
- Iprindole.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 200px
- Drug.image2
- Iprindole molecule ball.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 200px
- Drug.tradename
- Prondol, Galatur, Tertran
- Drug.legal_status
- Rx-only
- Drug.routes_of_administration
- Oral
- Drug.metabolism
- Hepatic
- Drug.elimination_half life
- 52.5 hours
- Drug.excretion
- Urine, Feces
- Drug.CAS_number
- 5560-72-5
- Drug.CAS_supplemental
- 20432-64-8 (hydrochloride)
- Drug.ATC_prefix
- N06
via Wikipedia infobox
Chemical data
- Formula
- C19H28N2
- Molecular weight
- 284.4 g/mol
- IUPAC name
- 3-(6,7,8,9,10,11-hexahydrocycloocta[b]indol-5-yl)-N,N-dimethylpropan-1-amine
- SMILES
- CN(C)CCCN1C2=C(CCCCCC2)C3=CC=CC=C31
- InChIKey
- PLIGPBGDXASWPX-UHFFFAOYSA-N
- XLogP
- 4.6
- Polar surface area
- 8.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- major depressive disorder
via ChEMBL · EBI
Research
319 papers- Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine.Cellular and molecular neurobiology · 1999
- Antidepressant overdosage.Drugs · 1982
- Iprindole: a cornerstone in the neurobiological investigation of antidepressant treatments.Modern problems of pharmacopsychiatry · 1982
- The effects of iprindole on noradrenergic transmission in the rat anococcygeus muscle.Naunyn-Schmiedeberg's archives of pharmacology · 1983
- Effects of neonatally administered iprindole on adult behaviors of rats.Pharmacology, biochemistry, and behavior · 1996
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 284.225
Show 5 more facts
- chemical formula
- C₁₉H₂₈N₂
- defined daily dose
- 90
- canonical SMILES
- CN(C)CCCN1C2=C(CCCCCC2)C3=CC=CC=C31
- subject has role
- tricyclic antidepressant
- Commons category
- Iprindole
Sources (3)
via Wikidata · CC0