KLK11

Also known as PRSS20, TLSP, kallikrein related peptidase 11

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.

Gene data

KLK11

Name: kallikrein related peptidase 11
Type: protein-coding
Position: 51,022,216–51,028,039 (−)
Aliases: IEKD, PRSS20, TLSP
Ensembl: ENSG00000167757
RefSeq RNA: NM_001136032.3, NM_001167605.2, NM_006853.3, NM_144947.3, XM_005258439.4
RefSeq protein: NP_001129504.1, NP_001161077.1, NP_006844.1, NP_659196.1, XP_005258496.1

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed. [provided by RefSeq, Dec 2016].

Gene Ontology

Biological process

proteolysis protein maturation

Molecular function

serine-type endopeptidase activity serine-type endopeptidase activity serine-type peptidase activity hydrolase activity

Cellular component

extracellular region extracellular region extracellular region Golgi apparatus secretory granule extracellular exosome

via MyGene.info

Gene · Ensembl

kallikrein related peptidase 11

Symbol: KLK11
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:51,022,216-51,028,060
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 27048
exact match: identifiers.org/ncbigene/11012
genomic end: 51531295
genomic start: 51525472
cytogenetic location: 19q13.41

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Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed.