MAP4K4
Sign in to saveAlso known as FLH21957, HEL-S-31, HGK, MEKKK4, NIK, mitogen-activated protein kinase kinase kinase kinase 4
gene umano
In the Vinony graph
Vinony's link graph records 5 inbound references to MAP4K4, and connects out to PubMed, Ensembl genome database project and cancer.
It is catalogued under the topic Genes on human chromosome 2.
Vinony links it to 5 Wikipedia language editions.
Gene data
MAP4K4- Name
- mitogen-activated protein kinase kinase kinase kinase 4
- Type
- protein-coding
- Aliases
- FLH21957, HEL-S-31, HGK, MEKKK4, NIK
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
mitogen-activated protein kinase kinase kinase kinase 4
- Symbol
- MAP4K4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 2:101,696,850-101,894,690
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- 4obo.png
Show 8 more facts
- HomoloGene ID
- 7442
- exact match
- identifiers.org/ncbigene/9448
- found in taxon
- Homo sapiens
- genomic end
- 102511149
- genomic start
- 102313312
- chromosome
- human chromosome 2
- cytogenetic location
- 2q11.2
- expressed in
- amygdala
Sources (4)
via Wikidata · CC0