MST1R
Sign in to saveAlso known as CD136, CDw136, PTK8, RON, macrophage stimulating 1 receptor, NPCA3, SEA
Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene. MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.
Gene data
MST1R- Name
- macrophage stimulating 1 receptor
- Type
- protein-coding
- Aliases
- CD136, CDw136, NPCA3, PTK8, RON, SEA, p185-Ron
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016].
via MyGene.info
Gene · Ensembl
macrophage stimulating 1 receptor
- Symbol
- MST1R
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 3:49,886,902-49,906,130
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 1835
- exact match
- identifiers.org/ncbigene/4486
- genomic end
- 49941299
- genomic start
- 49924435
- cytogenetic location
- 3p21.31
Sources (3)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Interactions
- References
- Further reading
Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene. MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.
== Interactions ==
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