MXD4
Sign in to saveAlso known as MAD4, MST149, MSTP149, bHLHc12, MAX dimerization protein 4
Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.
Gene data
MXD4- Name
- MAX dimerization protein 4
- Type
- protein-coding
- Position
- 2,247,432–2,262,115 (−)
- Aliases
- MAD4, MST149, MSTP149, bHLHc12
- Ensembl
- ENSG00000123933
- RefSeq RNA
- NM_006454.3
- RefSeq protein
- NP_006445.1
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4712
- exact match
- identifiers.org/ncbigene/10608
- genomic end
- 2262109
- genomic start
- 2249159
- cytogenetic location
- 4p16.3
Sources (4)
via Wikidata · CC0
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Article
4 sectionsContents
- Function
- References
- Further reading
- External links
Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.
== Function ==