Structure via PubChem · Public domain (PubChem)
oxotremorine
Sign in to saveOxotremorine is a drug that acts as a selective muscarinic acetylcholine receptor agonist.
In the Vinony graph
Vinony's link graph records 620 inbound references to oxotremorine, and connects out to atropine, muscarinic acetylcholine receptor family and medication.
Vinony files it under Alkyne derivatives, Chemical pages without DrugBank identifier and Drugboxes which contain changes to verified fields.
Vinony links it to 8 Wikipedia language editions.
Chemical data
- Formula
- C12H18N2O
- Molecular weight
- 206.28 g/mol
- IUPAC name
- 1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidin-2-one
- SMILES
- C1CCN(C1)CC#CCN2CCCC2=O
- InChIKey
- RSDOPYMFZBJHRL-UHFFFAOYSA-N
- XLogP
- 0.4
- Polar surface area
- 23.6 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
2,914 papers- Pharmacological properties of oxotremorine and its analogs.Life sciences · 1983
- Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms.Biochemical and biophysical research communications · 2018
- Effects of oxotremorine on convulsions in mice induced by scopolamine and food intake after fasting.Behavioural brain research · 2025
- Oxotremorine-M activates single nicotinic acetylcholine receptor channels in cultured Xenopus myocytes.European journal of pharmacology · 1994
- IMPROVED SYNTHESIS OF OXOTREMORINE.Journal of medicinal chemistry · 1965
via PubMed
Wikidata facts
- Mass
- 206.142
Show 4 more facts
- chemical formula
- C₁₂H₁₈N₂O
- subject has role
- muscarinic agonist
- canonical SMILES
- C1CCN(C1)CC#CCN2CCCC2=O
- Commons category
- Oxotremorine
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Oxotremorine is a drug that acts as a selective muscarinic acetylcholine receptor agonist.
Oxotremorine produces ataxia, tremor and spasticity, similar to those symptoms seen in Parkinsonism, and has thus become a research tool in experimental studies aimed at determining more effective anti-Parkinsonian drugs.
Excerpted from Wikipedia’s “oxotremorine” article, available under the CC BY-SA 4.0 licence.