Riluzol

Riluzole is a medication used to treat amyotrophic lateral sclerosis (ALS) and other motor neuron diseases. Riluzole delays the onset of ventilator-dependence or tracheostomy in some people and may increase survival by two to three months. Riluzole is available in tablet and liquid form. A thin film version of riluzole which dissolves on the tongue (commercially known as Exservan or Emylif) is available in the United States and United Kingdom.

In the Vinony graph

Within Vinony's link graph, Riluzol is referenced by 547 other articles, and connects out to ginkgolide, γ-aminobutyric acid and valproic acid.

Vinony files it under Benzothiazoles, Drugs with non-standard legal status and Drugs with unknown mechanisms of action.

Its subject is documented across 26 Wikipedia language editions.

Chemical data

Formula: C8H5F3N2OS
Molecular weight: 234.2 g/mol
IUPAC name: 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
SMILES: C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
InChIKey: FTALBRSUTCGOEG-UHFFFAOYSA-N
XLogP: 3.6
Polar surface area: 76.4 Å²
H-bond donors: 1
H-bond acceptors: 7
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1995
Admin. routes: oral
Indications: post-traumatic stress disorder, autism spectrum disorder, cutaneous melanoma, obsessive-compulsive disorder

via ChEMBL · EBI

Research

2,265 papers

Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).The Cochrane database of systematic reviews · 2012
The pharmacology and mechanism of action of riluzole.Neurology · 1996
Riluzole for the treatment of amyotrophic lateral sclerosis.Neurodegenerative disease management · 2020
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group.The New England journal of medicine · 1994
Riluzole.Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases · 2000

via PubMed

Wikidata facts

Mass: 234.007468
Has use: medication

Show 5 more facts

chemical formula: C₈H₅F₃N₂OS
medical condition treated: ALS
canonical SMILES: C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
defined daily dose: 0.1
Commons category: Riluzole

Sources (8)

via Wikidata · CC0

Article · Svenska

Riluzol (marknadsnamn Rilutek®) är ett läkemedel för att förlänga överlevnaden hos ALS-patienter som fortfarande kan andas själva. Exakt hur riluzol fungerar är inte klart, troligen hämmar det glutmatprocesser i nervsystemet. Glutamat är den vanligaste neuroexcitatoriska ämnet i nervsystemet och man tror att den kan vara inblandad i döden av neuron som sker vid ALS. Denna läkemedels- eller farmakologi-relaterade artikel saknar väsentlig information. Du kan hjälpa till genom att lägga till den.

Abstract from DBpedia / Wikipedia · CC BY-SA