Structure via PubChem · Public domain (PubChem)
Riluzole is a medication used to treat amyotrophic lateral sclerosis (ALS) and other motor neuron diseases. Riluzole delays the onset of ventilator-dependence or tracheostomy in some people and may increase survival by two to three months. Riluzole is available in tablet and liquid form. A thin film version of riluzole which dissolves on the tongue (commercially known as Exservan or Emylif) is available in the United States and United Kingdom.
Chemical data
- Formula
- C8H5F3N2OS
- Molecular weight
- 234.2 g/mol
- IUPAC name
- 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
- SMILES
- C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
- InChIKey
- FTALBRSUTCGOEG-UHFFFAOYSA-N
- XLogP
- 3.6
- Polar surface area
- 76.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1995
- Admin. routes
- oral
- Indications
- post-traumatic stress disorder, autism spectrum disorder, cutaneous melanoma, obsessive-compulsive disorder
via ChEMBL · EBI
Research
2,265 papers- Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).The Cochrane database of systematic reviews · 2012
- The pharmacology and mechanism of action of riluzole.Neurology · 1996
- Riluzole for the treatment of amyotrophic lateral sclerosis.Neurodegenerative disease management · 2020
- A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group.The New England journal of medicine · 1994
- Riluzole.Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases · 2000
via PubMed
Wikidata facts
- Mass
- 234.007468
- Has use
- medication
Show 5 more facts
- chemical formula
- C₈H₅F₃N₂OS
- medical condition treated
- ALS
- canonical SMILES
- C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
- defined daily dose
- 0.1
- Commons category
- Riluzole
Sources (8)
via Wikidata · CC0
Article · 中文
利鲁唑是赛诺菲推出的一种用来治疗肌萎缩性脊髓侧索硬化症的药物。它可以延迟部分病人依靠或进行氣管切開術的时间，从而延长约两至三个月的生命。
Abstract from DBpedia / Wikipedia · CC BY-SA