riluzole

composé chimique

In the Vinony graph

Vinony's link graph records 547 inbound references to riluzole, and connects out to ginkgolide, γ-aminobutyric acid and valproic acid.

It is catalogued under topics including Benzothiazoles, Drugs with non-standard legal status and Drugs with unknown mechanisms of action.

Vinony links it to 26 Wikipedia language editions.

Chemical data

Formula: C8H5F3N2OS
Molecular weight: 234.2 g/mol
IUPAC name: 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
SMILES: C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
InChIKey: FTALBRSUTCGOEG-UHFFFAOYSA-N
XLogP: 3.6
Polar surface area: 76.4 Å²
H-bond donors: 1
H-bond acceptors: 7
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1995
Admin. routes: oral
Indications: post-traumatic stress disorder, autism spectrum disorder, cutaneous melanoma, obsessive-compulsive disorder

via ChEMBL · EBI

Research

2,265 papers

Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).The Cochrane database of systematic reviews · 2012
The pharmacology and mechanism of action of riluzole.Neurology · 1996
Riluzole for the treatment of amyotrophic lateral sclerosis.Neurodegenerative disease management · 2020
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group.The New England journal of medicine · 1994
Riluzole.Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases · 2000

via PubMed

Wikidata facts

Mass: 234.007468
Has use: medication

Show 5 more facts

chemical formula: C₈H₅F₃N₂OS
medical condition treated: ALS
canonical SMILES: C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N
defined daily dose: 0.1
Commons category: Riluzole

Sources (8)

via Wikidata · CC0

Article · Français

Le riluzole est un médicament utilisé pour traiter la sclérose latérale amyotrophique. Il interfère dans l'utilisation du glutamate, mais son mode d'action n'est pas clairement élucidé.

Abstract from DBpedia / Wikipedia · CC BY-SA