Structure via PubChem · Public domain (PubChem)
URB597
Sign in to saveAlso known as URB 597, URB-597, KDS-4103
EX-597 (former developmental code names URB-597, KDS-4103, and ORG-231295) is a fatty acid amide hydrolase inhibitor (FAAH inhibitor) which is under development for the treatment of social anxiety disorder (or social phobia) and post-traumatic stress disorder (PTSD).
Chemical data
- Formula
- C20H22N2O3
- Molecular weight
- 338.4 g/mol
- IUPAC name
- [3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate
- SMILES
- C1CCC(CC1)NC(=O)OC2=CC=CC(=C2)C3=CC(=CC=C3)C(=O)N
- InChIKey
- ROFVXGGUISEHAM-UHFFFAOYSA-N
- XLogP
- 3.8
- Polar surface area
- 81.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 1
- Molecule type
- Small molecule
- Indications
- schizophrenia
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 338.163043
Show 2 more facts
- chemical formula
- C₂₀H₂₂N₂O₃
- canonical SMILES
- C1CCC(CC1)NC(=O)OC2=CC=CC(=C2)C3=CC(=CC=C3)C(=O)N
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- Further reading
EX-597 (former developmental code names URB-597, KDS-4103, and ORG-231295) is a fatty acid amide hydrolase inhibitor (FAAH inhibitor) which is under development for the treatment of social anxiety disorder (or social phobia) and post-traumatic stress disorder (PTSD).
It is a relatively selective and irreversible inhibitor of the enzyme fatty acid amide hydrolase (FAAH). FAAH is the primary degradatory enzyme for the endocannabinoid anandamide and, as such, inhibition of FAAH leads to an accumulation of anandamide in the CNS and periphery where it activates cannabinoid receptors. EX-597 has been found to elevate anandamide levels and have activity against neuropathic pain in a mouse model.
Excerpted from Wikipedia’s “URB597” article, available under the CC BY-SA 4.0 licence.