ADGRE2
Sign in to saveAlso known as CD312, VBU, EMR2, adhesion G protein-coupled receptor E2, CD97
EGF-like module-containing mucin-like hormone receptor-like 2 also known as CD312 (cluster of differentiation 312) is a protein encoded by the ADGRE2 gene. EMR2 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
In the Vinony graph
Within Vinony's link graph, ADGRE2 is referenced by 833 other articles, and connects out to PubMed, Ensembl genome database project and CD1.
It is catalogued under topics including Adhesion G protein-coupled receptors, Clusters of differentiation and Genes on human chromosome 19.
Its subject is documented across 8 Wikipedia language editions.
Gene data
ADGRE2- Name
- adhesion G protein-coupled receptor E2
- Type
- protein-coding
- Position
- 14,731,152–14,778,560 (−)
- Aliases
- CD312, CD97, EMR2, VBU
- Ensembl
- ENSG00000127507
- RefSeq RNA
- NM_001271052.1, NM_013447.4, NM_152916.2, NM_152917.2, NM_152918.1
- RefSeq protein
- NP_001257981.1, NP_038475.2, NP_690880.1, NP_690881.1, XP_011526250.1
This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
adhesion G protein-coupled receptor E2
- Symbol
- ADGRE2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:14,731,152-14,778,560
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein EMR2 PDB 2bo2.png
Show 8 more facts
- HomoloGene ID
- 113735
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/30817
- genomic end
- 14778560
- genomic start
- 14732392
- chromosome
- human chromosome 19
- cytogenetic location
- 19p13.12
- expressed in
- gallbladder
Sources (3)
via Wikidata · CC0
~4 min read
Encyclopedic overview
7 sectionsContents
- Ligand
- Signaling
- Function
- Clinical significance
- See also
- References
- External links
EGF-like module-containing mucin-like hormone receptor-like 2 also known as CD312 (cluster of differentiation 312) is a protein encoded by the ADGRE2 gene. EMR2 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
EMR2 is expressed by monocytes/macrophages, dendritic cells and all types of granulocytes. In the case of EMR2 the N-terminal domains consist of alternatively spliced epidermal growth factor-like (EGF-like) domains. EMR2 is closely related to CD97 with 97% amino-acid identity in the EGF-like domains. The N-terminal fragment (NTF) of EMR2 presents 2-5 EGF-like domains in human. Mice lack the Emr2 gene. This gene is closely linked to the gene encoding EGF-like molecule containing mucin-like hormone receptor 3 EMR3 on chromosome 19.
Excerpted from Wikipedia’s “ADGRE2” article, available under the CC BY-SA 4.0 licence.