CD38
Sign in to saveAlso known as ADPRC1, ADPRC 1, CD38 molecule
CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.
Gene data
CD38- Name
- CD38 molecule
- Type
- protein-coding
- Position
- 15,778,275–15,853,232 (+)
- Aliases
- ADPRC 1, ADPRC1, cADPR1
- Ensembl
- ENSG00000004468
- RefSeq RNA
- NM_001775.4, NR_132660.2
- RefSeq protein
- NP_001766.2
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
CD38 molecule
- Symbol
- CD38
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:15,778,275-15,853,232
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein CD38 PDB 1yh3.png
Show 5 more facts
- HomoloGene ID
- 1345
- exact match
- identifiers.org/ncbigene/952
- genomic end
- 15853232
- genomic start
- 15779898
- cytogenetic location
- 4p15.32
via Wikidata · CC0
~7 min read
Article
10 sectionsContents
- History
- Tissue distribution
- Function
- Clinical significance
- Clinical application
- Inhibitors
- Aging studies
- References
- Further reading
- External links
CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B lymphocytes and natural killer cells. CD38 also functions in cell adhesion, signal transduction and calcium signaling.
In humans, the CD38 protein is encoded by the CD38 gene which is located on chromosome 4. CD38 is a paralog of CD157, which is also located on chromosome 4 (4p15) in humans.