CELSR3

Also known as CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1, ADGRC3, cadherin EGF LAG seven-pass G-type receptor 3

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.

In the Vinony graph

Within Vinony's link graph, CELSR3 is referenced by 488 other articles, and connects out to PubMed, Ensembl genome database project and cell surface receptor.

Vinony files it under Adhesion G protein-coupled receptors, Genes on human chromosome 3 and G protein-coupled receptors.

Its subject is documented across 5 Wikipedia language editions.

Gene data

CELSR3

Name: cadherin EGF LAG seven-pass G-type receptor 3
Type: protein-coding
Position: 48,636,463–48,662,886 (−)
Aliases: ADGRC3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1
Ensembl: ENSG00000008300
RefSeq RNA: NM_001407.3
RefSeq protein: NP_001398.2

This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013].

Gene Ontology

Biological process

cell adhesion homophilic cell-cell adhesion signal transduction cell surface receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway axonogenesis dopaminergic neuron axon guidance

Molecular function

transmembrane signaling receptor activity G protein-coupled receptor activity G protein-coupled receptor activity calcium ion binding protein binding

Cellular component

plasma membrane plasma membrane adherens junction membrane membrane

Pathways

GPCRs, Other

via MyGene.info

Gene · Ensembl

cadherin EGF LAG seven-pass G-type receptor 3

Symbol: CELSR3
Biotype: Protein coding
Organism: Homo sapiens
Location: 3:48,636,463-48,662,886
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 1077
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/1951
genomic end: 48662886
genomic start: 48636463
chromosome: human chromosome 3
cytogenetic location: 3p21.31

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

See also
References
Further reading
External links

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.

Excerpted from Wikipedia’s “CELSR3” article, available under the CC BY-SA 4.0 licence.