Structure via PubChem · Public domain (PubChem)
سویملین
Sign in to saveAlso known as Cevimelina, 2-Methyspiro(1,3-oxathiolane-5,3)quinuclidine, Sni 2011, Cevimelinum, Evoxac
Cevimeline (trade name Evoxac) is a synthetic analog of the natural alkaloid muscarine with a particular agonistic effect on M1 and M3 receptors. It is used in the treatment of dry mouth and Sjögren's disease.
In the Vinony graph
Vinony's link graph records 405 inbound references to سویملین, and connects out to atropine, muscarinic acetylcholine receptor family and International Standard Book Number.
It sits within the topics Daiichi Sankyo, Drugboxes which contain changes to verified fields and Drugboxes which contain changes to watched fields.
Vinony links it to 17 Wikipedia language editions.
Chemical data
- Formula
- C10H17NOS
- Molecular weight
- 199.32 g/mol
- IUPAC name
- 2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane]
- SMILES
- CC1OC2(CN3CCC2CC3)CS1
- InChIKey
- WUTYZMFRCNBCHQ-UHFFFAOYSA-N
- XLogP
- 1.5
- Polar surface area
- 37.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2000
- Admin. routes
- oral
- Indications
- xerostomia
via ChEMBL · EBI
Research
231 papers- Cevimeline.2012
- Neuropharmacology of Cevimeline and Muscarinic Drugs-Focus on Cognition and Neurodegeneration.International journal of molecular sciences · 2021
- Cevimeline.Drugs · 2008
- EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies.Annals of the rheumatic diseases · 2020
- Xerostomia of Various Etiologies: A Review of the Literature.Advances in clinical and experimental medicine : official organ Wroclaw Medical University · 2016
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 199.103085
- Has use
- medication
Show 6 more facts
- chemical formula
- C₁₀H₁₇NOS
- subject has role
- muscarinic agonist
- canonical SMILES
- CC1OC2(CN3CCC2CC3)CS1
- defined daily dose
- 90
- medical condition treated
- Sjögren's syndrome
- Commons category
- Cevimeline
Sources (3)
via Wikidata · CC0